Therapeutic levetiracetam monitoring during pregnancy: “mind the gap”

“Mind the Gap” in Reporting the Outdated Statistics

Are doses of lamotrigine or levetiracetam adjusted during pregnancy?

Subtherapeutic levels of lamotrigine and levetiracetam are more likely to occur during pregnancy owing to the effect of pregnancy on their pharmacokinetics. This can lead to suboptimal control of epilepsy, and guidelines recommend proactive dose adjustment in the second and third trimesters alongside therapeutic drug monitoring (TDM). This retrospective cohort study using administrative databas...

Glucose Monitoring During Pregnancy

Self-monitoring of blood glucose in women with mild gestational diabetes has recently been proven to be useful in reducing the rates of fetal overgrowth and gestational weight gain. However, uncertainty remains with respect to the optimal frequency and timing of self-monitoring. A continuous glucose monitoring system may have utility in pregnant women with insulin-treated diabetes, especially f...

Mind the (Intelligibility) Gap

Intelligibility, evolution and emulation are some of the key notions for digital information preservation. In this paper we define formally these notions on the basis of modules and inter-module dependencies. Subsequently, we discuss how we can handle the evolution of modules and dependencies. This work can be exploited for building advanced preservation information systems and registries.

Mind the Gap!

In 1835, the French naturalist Felix Dujardin started crushing ciliates under the microscope and observed that the tiny cells exuded a jellylike, water-insoluble substance, which he described as a ‘‘gelée vivante’’ and which was eventually christened ‘‘protoplasm’’ by the physician Johann E. Purkinje and the botanist Hugo von Mohl. Fifty years after Dujardin’s observations, the possibility that...